May 2018May 2018
New Product - Vosevi
Vosevi (sofosbuvir/velpatasvir/voxilaprevir) is a fixed dose combination tablet containing the active substances sofosbuvir, velpatasvir and voxilaprevir. Sofosbuvir is a pan-genotypic inhibitor of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, which is essential for viral replication. Velpatasvir is a pan-genotypic HCV inhibitor targeting the HCV NS5A protein, which is essential for both RNA replication and the assembly of HCV virions. Voxilaprevir is a pan-genotypic inhibitor of the NS3/4A protease. Vosevi is indicated for the treatment of chronic HCV infection in adults, without cirrhosis or with compensated cirrhosis, who have: genotype 1, 2, 3, 4, 5, or 6 infection and have previously been treated with an HCV regimen containing an NS5A inhibitor; genotype 1a or 3 infection and have previously been treated with an HCV regimen containing sofosbuvir without an NS5A inhibitor. Vosevi is contraindicated with rifampicin and rosuvastatin. Vosevi (sofosbuvir 400 mg/velpatasvir 100 mg/voxilaprevir 100 mg) tablets are available in packs of 28.
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