October 2017

IMgateway Drug Herb and Food and Supplement Interaction Database

Recent updates to the Interactions Database

Recent updates to the Interactions Database
The Interactions Database continues to expand, now including over 1000 interactions. Recent additions include comprehensive advice on interactions between commonly consumed traditional medicines and supplements with a range of conventional medicines. New information includes interactions in the following areas:

Each interaction monograph contains specific advice for patient-management, critical appraisal of the evidence supporting the interaction, a commentary on the clinical significance of potential interactions, and recommended advice for consumers receiving the combination.

Recent additions to the database

Int no.
 Interaction Type of study Title
226
 Areca (Betel) nut + tacrolimus Human study Areca (Betel) nut reduces tacrolimus trough concentrations in liver transplant patients
227
 Long-Dan-Xie-Gan-Tang + sorafenib Animal study Long-Dan-Xie-Gan-Tang (LDXGT) appears to have no effect on sorafenib pharmacokinetics in rats
228
 Triptolide + sorafenib Animal study Triptolide reduces the oral clearance of sorafenib in rats
229
 Horsetail + antiretrovirals (lamivudine/ zidovudine/efavirenz, emtricitabine/ tenofovir) Human study Horsetail consumption induces virological breakthrough by interacting with antiretroviral therapy in HIV patients
230
 Andrographis + naproxen Animal study Andrographis paniculata Nees extract and andrographolide affect naproxen pharmacokinetics in rats
231
 Ginkgo biloba + clopidogrel Animal study Ginkgo biloba increases the systemic exposure of clopidogrel's active metabolite in rats
232
 Antrodia cinnamomea + chemotherapeutic agents Human study Antrodia cinnamomea reduces platelet count when given with chemotherapy regimens
233
 Agaricus blazeii Murrill + chemotherapeutic agents Human study ABM mushrooms appear to have no effect on chemotherapy in multiple myeloma (cyclophosphamide)

This list is a summary of only some of the changes that have occurred over the last month. Before prescribing, always refer to the full product information.

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