July 2017

New Contraindications

Codeine (Panamax Co, Prodeinextra (paracetamol/codeine phosphate hemihydrate), Mersyndol, Panalgesic (paracetamol/codeine phosphate hemihydrate/doxylamine succinate)) is now contraindicated in the event of impending childbirth or in case of risk of premature birth.

Phenobarbitone Injection (Aspen Pharma) (phenobarbital (phenobarbitone)) is now contraindicated in acute intoxication with alcohol, hypnotics or analgesics or intoxication with stimulants or depressant psychotropic agents.

Pregnyl (human chorionic gonadotrophin) is now contraindicated with abnormal (not menstrual) vaginal bleeding without a known/ diagnosed cause.

Serenace (haloperidol), in common with other neuroleptics, has the potential to cause rare prolongation of the QT interval. Use of haloperidol is therefore contraindicated with clinically significant cardiac disorders, history of ventricular arrhythmia or torsades de pointes, and uncorrected hypokalaemia. Haloperidol should not be used concomitantly with other QT prolonging drugs.

Varilrix and Varilrix HSA-Free (varicella vaccine, live attenuated) are contraindicated with severe humoral or cellular immunodeficiency.

Viekira Pak Combination Therapy Pack (paritaprevir/ritonavir/ombitasvir and dasabuvir) is now also contraindicated in moderate hepatic impairment (Child-Pugh B) due to risk of potential toxicity.

This list is a summary of only some of the changes that have occurred over the last month. Before prescribing, always refer to the full product information.

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