March 2017March 2017
New Product - Nocdurna
Nocdurna (desmopressin (as hydrated acetate)) is a synthetic structural analogue of the natural pituitary hormone, arginine vasopressin. The difference lies in the desamination of cysteine and substitution of L-arginine by D-arginine. Desmopressin mimics vasopressin’s antidiuretic effect, binding to the V2 receptors in the renal collecting tubules of the kidneys, causing reabsorption of water into the body. This reabsorption in turn decreases night time urine production. Nocdurna is indicated for the treatment of nocturia due to idiopathic nocturnal polyuria in adults who awaken two or more times each night to void and have not responded to lifestyle measures. Nocturnal polyuria should be confirmed on the basis of a 24 hour urine frequency volume diary. It is defined as > 33% of urine passed overnight. Secondary causes of nocturia should be excluded. Nocdurna is contraindicated in the following conditions. Habitual or psychogenic polydipsia (resulting in a urine production exceeding 40 mL/kg/24 hours); a history of known or suspected cardiac insufficiency and other conditions requiring treatment with diuretics; moderate and severe renal insufficiency (creatinine clearance below 50 mL/min or an eGFR below 45 mL/min/1.73 m2); known history of hyponatraemia; patients with cognitive impairment who may not be expected to comply with the fluid intake restriction recommendations when taking Nocdurna; syndrome of inappropriate antidiuretic hormone secretion (SIADH) and conditions that predispose the patient to SIADH; conditions associated with abnormal electrolytes such as nausea, eating disorders, chronic vomiting or diarrhoea, adrenal insufficiency, nephropathy. Nocdurna is available as 25 microgram and 50 microgram sublingual wafers in packs of 30’s.
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