New Product - Folotyn
Folotyn (pralatrexate) is an antineoplastic folate analogue that is a substrate for reduced folate transporters, including reduced folate carrier 1 (RFC-1) and the enzyme folylpolyglutamyl synthetase (FPGS), resulting in internalisation and accumulation within tumour cells. Pralatrexate exerts antifolate activity via the inhibition of dihydrofolate reductase (DHFR), resulting in a disruption of DNA synthesis and subsequent tumour cell death. Folotyn is indicated for the treatment of adults with peripheral T cell lymphoma (nodal, extranodal, and leukaemic/ disseminated) who have progressed after at least one prior therapy. Folotyn is contraindicated during breastfeeding. Folotyn is available as a 20 mg/1 mL and 40 mg/2 mL solution for infusion in pack sizes of 1 vial.
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