March 2017

IMgateway Drug Herb and Food and Supplement Interaction Database

Recent updates to the Interactions Database

The Interactions Database continues to expand, now including over 950 interactions . Recent additions include comprehensive advice on interactions between commonly consumed traditional medicines, supplements with a range of conventional medicines. New information includes interactions in the following areas:

Each interaction monograph contains specific advice on the evidence supporting the interaction, a commentary on the clinical significance of potential interactions, and recommended advice for consumers receiving the combination.

Recent additions to the database

163 NAC + antimicrobials Human studies Effect of N-acetylcysteine on inflammation biomarkers in pediatric acute pyelonephritis: a randomized controlled trial
164 NAC + clomiphene citrate Human studies The adjuvant effect of metformin and N-acetylcysteine to clomiphene citrate in induction of ovulation in patients with Polycystic Ovary Syndrome.
165 Bitter melon + antidiabetic medication Human studies Phytochemical determination and extraction of Momordica charantia fruit and its hypoglycemic potentiation of oral hypoglycemic drugs in diabetes mellitus (NIDDM).
166 Cacao +  statins/aspirin/beta blockers/ACEI/ARB Human studies Improvement of Endothelial Function With Dietary Flavanols Is Associated With Mobilization of Circulating Angiogenic Cells in Patients With Coronary Artery Disease
167 HIBC (Colostrum) + Raltegravir Human studies Intensification of antiretroviral therapy with raltegravir or addition of hyperimmune bovine colostrum in HIV-infected patients with suboptimal CD4+ T-cell response: a randomized controlled trial.
168 Saffron (Crocus sativus)- Crocin + Anti-depressants (SSRIs) Human studies Crocin, the main active saffron constituent, as an adjunctive treatment in major depressive disorder: a randomized, double-blind, placebo-controlled, pilot clinical trial.
169 Saffron extract + Timolol and Dorzolamide Human studies The ocular hypotensive effect of saffron extract in primary open angle glaucoma: a pilot study.
170 Saffron/Crocin + Olanzapine Human studies Saffron aqueous extract prevents metabolic syndrome in patients with schizophrenia on olanzapine treatment: a randomized triple blind placebo controlled study.
171 SAMe + Anti-depressant medication Human studies Oral SAMe in Persistent Treatment-Refractory Bipolar Depression: A Double-Blind, Randomized Clinical Trial
172 SAMe + Ursodeoxycholic acid Human studies Ursodeoxycholic acid and S-adenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy: a multi-centered randomized controlled trial.

This list is a summary of only some of the changes that have occurred over the last month. Before prescribing, always refer to the full product information.

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