January 2017

IMgateway Drug Herb and Food and Supplement interaction database

Recent updates to the Interactions Database

The Interactions Database continues to expand, now including over 900 interactions. Recent additions include comprehensive advice on interactions between commonly consumed traditional medicines, supplements with a range of conventional medicines. New information includes interactions in the following areas:

Each interaction monograph contains specific advice on the evidence supporting the interaction, a commentary on the clinical significance of potential interactions, and recommended advice for consumers receiving the combination.

Recent additions to the database

151 Lavender oil + Microgynon (ethinyl estradiol/levonorgestrel combination) Human studies No interacting influence of lavender oil preparation silexan on oral contraception using an ethinyl estradiol/levonorgestrel combination.
152 Mauby + Warfarin Human studies Elevated International Normalized Ratio in a Patient Taking Warfarin and Mauby: A Case Report.
153 Chokeberry + Simvastatin Human studies Combination therapy of statin with flavonoids rich extract from chokeberry fruits enhanced reduction in cardiovascular risk markers in patients after myocardial infraction (MI).
154 Astaxanthin + immunosupressent drugs Human studies Astaxanthin has no effect on arterial stiffness, oxidative stress, or inflammation in renal transplant recipients: a randomized controlled trial (the XANTHIN trial).
155 Baicalin + Rosuvastatin Human studies The effect of herbal medicine baicalin on pharmacokinetics of rosuvastatin, substrate of organic anion-transporting polypeptide 1B1.
156 Saccharomyces + bismuth subsalicylate Human studies Saccharomyces boulardii and bismuth subsalicylate as low-cost interventions to reduce the duration and severity of cholera.
157 Fish/krill oil +Warfarin Human studies The Use of Fish Oil with Warfarin Does Not Significantly Affect either the International Normalised Ratio or Incidence of Adverse Events in Patients with Atrial Fibrillation and Deep Vein Thrombosis: A Retrospective Study.
158 Krill oil +Cholesterol lowering medication Human studies Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia.
159 L-theanine + Antipsychotic medication Human studies Effect of L-theanine on glutamatergic function in patients with schizophrenia.
160 L-theanine + antipsychotic medication Human studies Serum levels of brain-derived neurotrophic factor and cortisol to sulfate of dehydroepiandrosterone molar ratio associated with clinical response to L-theanine as augmentation of antipsychotic therapy in schizophrenia and schizoaffective disorder patients.
161 Glutamine +¬† oral hypoglycemic, antihypertensive, and antihyperlipidemic agents Human studies Effect of glutamine supplementation on cardiovascular risk factors in patients with type 2 diabetes.
162 Glutamine + sitagliptin Human studies Glycemic effects and safety of L-Glutamine supplementation with or without sitagliptin in type 2 diabetes patients-a randomized study.

This list is a summary of only some of the changes that have occurred over the last month. Before prescribing, always refer to the full product information.

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