November 2016November 2016
New Product - Prezcobix
Prezcobix (darunavir/cobicistat) is a fixed dose antiviral for systemic use. Darunavir is an inhibitor of Human mmunodeficiency virus type 1 (HIV 1) protease and Cobicistat is a mechanism based inhibitor of cytochrome P450 (CYP) enzymes of the CYP3A family. Prescobix, is indicated in combination with other antiretroviral agents for the treatment of adult patients with human immunodeficiency virus-1 (HIV-1) infection in: antiretroviral treatment naive patients; antiretroviral treatment experienced patients with no darunavir resistance associated mutations and who have plasma HIV-1 RNA < 100,000 copies/mL and in antiretroviral treatment experienced but HIV protease inhibitor naive patients for whom HIV-1 genotype testing is unavailable. Contraindications: Prezcobix should not be coadministered with medicinal products that are highly dependent on CYP3A for clearance and for which increased plasma concentrations are associated with serious and/or life threatening events (narrow therapeutic index). These medicinal products include alfuzosin, astemizole, apixaban, cisapride, colchicine (in patients with renal and/or hepatic impairment), dronedarone, lovastatin, oral midazolam, pimozide, ranolazine, ergot alkaloids (e.g., dihydroergotamine, ergotamine, ergonovine and methylergonovine), sildenafil (when used for treatment of pulmonary arterial hypertension), simvastatin, terfenadine, and triazolam and antiarrhythmic drugs (e.g. amiodarone, bepridil, flecainide, systemic lidocaine, quinidine). Coadministration of Prezcobix with CYP3A inducers may lead to lower exposures of darunavir and cobicistat and potential loss of efficacy of darunavir and possible resistance. Patients taking Prezcobix should not use products containing carbamazepine, phenobarbital, phenytoin, rifampin or St. John’s wort. Prezcobix tablets containing 800 mg darunavir and 150 mg cobicistat is available in bottles of 30's.
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