Kaletra (lopinavir/ritonavir) should not be coadministered concurrently with drugs that are highly dependent on CYP3A for clearance and for which elevated plasma concentrations are associated with serious and/or life threatening events including colchicine in patients with renal and/or hepatic impairment and dronedarone.
Ketoral (ketorolac trometamol) is now also contraindicated in those undergoing treatment of perioperative pain in setting of coronary artery surgery (CABG) and those with severe hepatic impairment.
Parnate (tranylcypromine sulfate) is now contraindicated with nefopam; in patients with known porphyria and in patients with hyperthyroidism.
Xiaflex (collagenase clostridium histolyticum) - do not use for the treatment of Peyronie’s plaques that involve the penile urethra due to potential risk to this structure.
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