Cordilox SR (verapamil hydrochloride) is now contraindicated in the following situations. Patients concomitantly administered ivabradine; simultaneous initiation of treatment with dabigatran etexilate and oral verapamil; and in treatment initiation with oral verapamil in patients following major orthopaedic surgery who are already treated with dabigatran etexilate.
Ikorel (nicorandil) is now also contraindicated in patients with severe hypotension or with a risk of developing severe hypotension including acute myocardial infarction with acute left ventricular failure and low filling pressures and hypovolaemia. It is also now contraindicated in patients receiving any soluble guanylate cyclase stimulators.
Solu‑medrol (methylprednisolone sodium succinate) is now also contraindicated in the following. The 40 mg Act‑O‑Vial presentation includes lactose produced from cow’s milk. This presentation may contain trace amounts of milk ingredients and is therefore contraindicated in patients with a known hypersensitivity to cow’s milk or its components, or to other dairy products.
Truvada (tenofovir disoproxil fumarate; emtricitabine) is now also contraindicated for pre-exposure prophylaxis in individuals with unknown or positive HIV‑1 status.
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