Safety Related Changes
Skelid (tiludronate disodium) should not be used in juvenile Pagetic patients as safety and efficacy has not been established.
Valoid (cyclizine lactate) should not be given to patients who have acute myocardial infarction. Valoid should also not be given to patients who have acute alcohol intoxication. The anti‑emetic properties of cyclizine may increase the toxicity of alcohol.
Voltaren (diclofenac sodium) is now contraindicated in patients with severe hepatic impairment. Voltaren is now also contraindicated in the treatment of perioperative pain in setting of coronary artery bypass surgery (CABG).
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