Safety Related Changes
The combination of Adcirca (tadalafil) and guanylate cyclase stimulators, such as riociguat, is contraindicated because it may lead to symptomatic hypotension.
Imrest (zopiclone) is now contraindicated with prior or concomitant use of alcohol.
Concomitant use of Nitrolingual Pumpspray (glyceryl trinitrate) with soluble guanylate cyclase stimulators is now contraindicated due to an increased risk of hypotension.
Oruvail SR Capsules (ketoprofen) and Orudis SR Capsules and Suppositories (ketoprofen) are contraindicated in the treatment of perioperative pain in the setting of coronary artery bypass surgery (CABG).
Xgeva (denosumab) is now contraindicated in the presence of unhealed lesions from dental or oral surgery
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