April 2016

Safety Related Changes

The combination of Adcirca (tadalafil) and guanylate cyclase stimulators, such as riociguat, is contraindicated because it may lead to symptomatic hypotension.

Imrest (zopiclone) is now contraindicated with prior or concomitant use of alcohol.

Concomitant use of Nitrolingual Pumpspray (glyceryl trinitrate) with soluble guanylate cyclase stimulators is now contraindicated due to an increased risk of hypotension.

Oruvail SR Capsules (ketoprofen) and Orudis SR Capsules and Suppositories (ketoprofen) are contraindicated in the treatment of perioperative pain in the setting of coronary artery bypass surgery (CABG).

Xgeva (denosumab) is now contraindicated in the presence of unhealed lesions from dental or oral surgery

This list is a summary of only some of the changes that have occurred over the last month. Before prescribing, always refer to the full product information.

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