New Product - Tybost
Tybost (cobicistat) is a selective, mechanism based inhibitor of cytochrome P450 (CYP) enzymes of the CYP3A family. Inhibition of CYP3A mediated metabolism by cobicistat enhances the systemic exposure of CYP3A substrates, such as atazanavir or darunavir. Tybost is indicated as a pharmacokinetic enhancer of appropriate HIV‑1 protease inhibitors in adults. Tybost is contraindicated with the following medicines. Alpha1‑adrenoreceptor antagonist alfuzosin; anticonvulsants carbamazepine, phenobarbitone, phenytoin; antimycobacterials rifabutin, rifampicin, rifapentine; ergot derivatives dihydroergotamine, ergonovine, ergotamine, methylergonovine; gastrointestinal motility agent cisapride; herbal product St John’s wort; HMG‑CoA reductase inhibitors lovastatin, simvastatin; neuroleptic pimozide; phosphodiesterase‑5 (PDE‑5) inhibitors sildenafil and tadalafil for the treatment of pulmonary arterial hypertension; and orally administered sedative/hypnotics midazolam, triazolam. Tybost is available as 150 mg tablets in packs of 30’s.
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