January 2015January 2015
New Product - Jardiamet
Jardiamet (empagliflozin + metformin) contains a reversible competitive inhibitor of SGLT2 and a biguanide with antihyperglycaemic effects respectively. It is indicated as an adjunct to diet and exercise to improve glycaemic control in adult patients with type 2 diabetes mellitus who are inadequately controlled with metformin or empagliflozin alone; those inadequately controlled with empagliflozin or metformin in combination with other glucose lowering products including insulin; and in those already treated with empagliflozin and metformin coadministered as separate tablets. Jardiamet is contraindicated in patients with the following conditions. Diabetic ketoacidosis; diabetic pre‑coma; renal failure or renal dysfunction (creatinine clearance < 60 mL/min); acute conditions with the potential to alter renal function such as: dehydration, severe infection, shock, intravascular administration of iodinated contrast agents; acute or chronic disease which may cause tissue hypoxia such as: cardiac or respiratory failure, recent myocardial infarction, shock, pulmonary embolism, acute significant blood loss, sepsis, gangrene, pancreatitis; and during or immediately following surgery where insulin is essential. Due to its metformin component, Jardiamet is contraindicated in patients with conditions which can lead to severe hepatic insufficiency such as acute alcohol intoxication and alcoholism. Jardiamet is available in 4 strengths namely Jardiamet 5/500 containing empagliflozin 5 mg, metformin hydrochloride 500 mg; Jardiamet 5/1000 containing empagliflozin 5 mg, metformin hydrochloride 1000 mg; Jardiamet 12.5/500 mg containing empagliflozin 12.5 mg, metformin hydrochloride 500 mg and Jardiamet 12.5/1000 containing empagliflozin 12.5 mg, metformin hydrochloride 1000 mg respectively. Each of these strengths is available in packs of 60’s.
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