August 2015

Safety Related Changes

Advantan (methylprednisolone aceponate) is now contraindicated if ulcera or atrophic skin disease is present.

Dizole One (fluconazole) is now contraindicated with coadministration of the QT prolonging drug erythromycin.

Epilim (sodium valproate), Epilim IV (sodium valproate) are now contraindicated in patients known to have mitochondrial disorders caused by mutations in the nuclear gene encoding mitochondrial enzyme polymerase gamma (POLG eg Alpers-Huttenlocher syndrome) and in children under two years of age who are suspected of having POLG related disorder.

This list is a summary of only some of the changes that have occurred over the last month. Before prescribing, always refer to the full product information.

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