Safety Related Changes
Do not coadminister Avapro HCT (irbesartan/ hydrochlorothiazide) with ACE inhibitors in patients with diabetic nephropathy.
Mersyndol Forte (paracetamol, codeine phosphate, doxylamine succinate) is now contraindicated in children under 18 years undergoing tonsillectomy and/or adenoidectomy to treat obstructive sleep apnoea, and in patients who are ultrarapid CYP2D6 metabolisers.
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